Dithiol Compounds at Low Concentrations Increase Arsenite Toxicity
نویسندگان
چکیده
منابع مشابه
Dithiol compounds at low concentrations increase arsenite toxicity.
Inorganic trivalent arsenicals are vicinal thiol-reacting agents, and dithiothreitol (DTT) is a well-known dithiol agent. Interestingly, both decreasing and increasing effects of DTT on arsenic trioxide-induced apoptosis have been reported. We now provide data to show that, at high concentrations, DTT, dimercaptosuccinic acid (DMSA), and dimercaptopropanesulfonic acid (DMPS) decreased arsenic t...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2006
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfj108